A new study has investigated how mothers & fathers cause new genetic mutations in their children, & how some of these mutations may lead to negative outcomes.
Characteristics that we inherit from our parents – starting with very basic features such as eye color or hair Structure – shape not just our identity, but Apparently the state of our health, both earlier and later in life.
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That being the case, the study of genetics has become central to understanding who and what You are, as well as how our bodies are likely to develop in time, and how You might respond to internal or external factors.
For instance, recent studies have revealed the importance of genetic factors to conditions including Alzheimer's disease, brain cancer, radiologyebook.net/video-medical And diabetes.
Given the importance of understanding the role of genetic factors to our health profile, scientists are constantly striving to decipher the mysteries of the human genome.
A new study conducted by researchers at deCODE genetics in Reykjavik, Iceland, has revealed that the parents' age at the time of conception influences de novo mutations (DNMs) in children – that is, genetic changes that are seen in the offspring, but not in their parents.
Senior study author Dr. Kári Stefánsson, the chief executive officer of deCODE genetics, told Medical News today that this research is very Important to understanding how & why Single childhood diseases occur.
"Now […] it is clear," he said, "that DNMs are responsible for a very large percentage of Individual diseases of childhood. So it's extraordinarily Important from a clinical point of view to understand the way in which DNMs are generated, to understand whether they are coming from the mother or Father, how They are When us come from one but not the other."
Definitely more DNMs are caused by older fathers
Dr. Stefánsson And colleagues analyzed genome data from 14,688 individuals across the general population of Iceland. From these, They focused Above 1,548 trios of parents and children. us Also analyzed the Begin of DNMs across three generations in 225 of the participants.
They sought to map out the interactions between parental sex & age And the type of genetic mutations that occur in the children, as well as the location of these mutations in the genome.
Following the researchers' analysis, They found that the number of DNMs caused By means of the mothers increases by 0.37 with each year of age. In the case of DNMs influenced By means of fathers, their number increases By means of 1.51 per year, making paternal influence almost four times stronger in this context.
"In this paper," Dr. Stefánsson explained to they, "we focus very much on the difference between the maternally derived And the paternally derived DNMs And You show that indeed there is a difference in what kind of mutations you're most likely to get from the mother & Father."
"The total number of genome mutations that come from the Father is about four times greater than [that which] comes from the mother," he added.
However, DNMs caused by the mother are equal in number to DNMs caused By means of the father in around 10 percent of the genome, the researchers noted. Besides, most maternal DNMs in these regions of the genome are C-to-G transversion mutations, leading to genome strand breaks.
This can affect the break in which a gene works, or even whether it works at all, and such mutations can sometimes lead to a risk of developing certain diseases.
Source: General online